| Tissue engineering |
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Tissue engineering is the combination of science and mechanics for the reconstruction of the human myoskeletic system. It is a method that combines a variety of biological and mechanical issues for the creation of functional tissues and organs for implantation. Tissue engineering is based on tissue removal from a patient, its culture expansion and the use of a bio-scaffold. The new blood vessels are being developed in the novel tissue, the scaffold is being dissolved and the novel tissue is connected with the surrounding ones. Using the tissue engineering new tissues such as skin, cartilage, bone, liver, neurons and vessels could be constructed. The scaffolds consist of structures such as pores, fibers or membranes that can be arranged randomly. The best structural and nutritional conditions for the development of a new tissue are obtained with the use of a biologically structured 3D tissue as a matrix. Tissue engineering uses solid scaffolds as matrices for the development of novel tissues.
References Binil Starly. "Biomimetic design and fabrication of tissue engineered scaffolds using computer aided tissue engineering". A thesis, submitted to the faculty of Drexel University, 2006. Joseph P Vacanti, Robert Langer. "Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation". Molecular Medicine 354 (1999) 32 - 34. Wei Sun, Pallavi Lal. "Recent development on computer aided tissue engineering - a review". Computer Methods and Programs in Biomedicine 67 (2002) 85 - 103. Jennifer J. Marler, Joseph Upton, Robert Langer, Joseph P. Vacanti. "Transplantation of cells in matrices for tissue regeneration". Advanced Drug Delivery Reviews 33 (1998) 165 - 182. Bram G. Sengers, Mark Taylor, Colin P. Please, Richard O. C. Oreffo. "Review - Computational modeling of cell spreading and tissue regeneration in porous scaffolds". Biomaterials 28 (2007) 1926 - 1940. Io Alexandropoulou (2007). Tissue Engineering: creation of a digital and physical implantation model for the reconstruction of the cranial bone. Diploma Thesis, Department of Product and Systems Design Engineering -University of the Aegean. |














